Mechanisms that support long-term autoimmune CD4 T cell persistence and function are still unresolved. Aljobaily et al. demonstrate that epigenetic programing of autoimmune CD4 T cells allows fine-tuning of TCF1 transcription factor activity to balance survival and effector function. Free access here: https://authors.elsevier.com/a/1jwHf3qNrUxuMx
Comments